Nanofibers for delivery of Bioactivesadmin2019-03-12T11:34:30+00:00
Entrapment of bioactives in polymeric matrices has shown to be a promising solution to preserve their viability during production and storage of formulations (de Voset al., 2010). There are many industrial processes for entrapping bioactives in polymeric matrices, which include spray drying, film extrusion, melt blowing, etc. Although successful in entrapping the bio-actives, the conventional polymeric matrices display a lower loading capacity and interactive surface for catalysis and release, when compared to nano-structured polymeric structures. Therefore, researchers across the globe are seeking solutions for entrapping bioactives in nanostructures.
One of the recent and efficient methods of entrapping bioactives is by the use of Nanofibers.
Nanofibers have a high surface area to volume ratio, allowing for significant interaction with their immediate micro-environment.
Therefore, these structures are preferred platforms for immobilization of sensing molecules, bio-active ligands and cell growth factors (Bhardwaj and Kundu, 2010). Further, the physical properties such as rate of degradation, porosity, mechanical strength, electrical conductivity, etc. can be tailored by choosing a suitable polymer or additive blends.
In addition, the chemical properties of the fibers can be altered to design matrices with superior catalytic and sensing capabilities.
At FIB-SOL, we have gone a step ahead by embedding live whole cells on to these nanofiber matrices.
Our fiber platforms provide an excellent matrix for loading plant beneficial microbes such as Azospirillum, Azotobacter, Rhizobium, etc. Using our technology we are able load 10-100 billion cells/g of fiber mat. This provides a highly efficient way of delivering these cells to the soil and crops.
Similar to cells, our fiber platforms have an extremely high surface .area to embed bio-molecules, ceramic particles and other industrial actives.